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Junji Magae Selected Research

ascochlorin

10/20204-O-methylascochlorin activates autophagy by activating AMPK and suppressing c-Myc in glioblastoma.
12/20194-O-methylascochlorin stabilizes hypoxia-inducible factor-1 in a manner different from hydroxylase inhibition by iron chelating or substrate competition.
7/2019Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages.
1/20194-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate.
1/2018Suppression of c-Myc enhances p21WAF1/CIP1 -mediated G1 cell cycle arrest through the modulation of ERK phosphorylation by ascochlorin.
1/2017Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy.
12/2016Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma.
4/2016Anti-Inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-κB, ERK1/2, and p38 Signaling Pathway.
4/2015Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3.
4/2012Ascochlorin inhibits growth factor-induced HIF-1α activation and tumor-angiogenesis through the suppression of EGFR/ERK/p70S6K signaling pathway in human cervical carcinoma cells.
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Junji Magae Research Topics

Disease

29Neoplasms (Cancer)
04/2023 - 09/2003
11Breast Neoplasms (Breast Cancer)
12/2013 - 04/2005
5Hypoxia (Hypoxemia)
12/2019 - 03/2011
3Leukemia
10/2020 - 05/2016
3Lung Neoplasms (Lung Cancer)
08/2020 - 01/2011
3Osteosarcoma (Osteogenic Sarcoma)
12/2019 - 10/2006
3Neoplasm Metastasis (Metastasis)
12/2016 - 07/2005
3Hypertension (High Blood Pressure)
04/2016 - 04/2002
3Carcinoma (Carcinomatosis)
04/2012 - 11/2007
2Adenocarcinoma
01/2019 - 03/2008
2Hepatocellular Carcinoma (Hepatoma)
12/2016 - 04/2015
2Insulin Resistance
06/2010 - 07/2009
2Fibrosis (Cirrhosis)
05/2009 - 05/2005
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2008 - 04/2007
1Uterine Cervical Neoplasms (Cancer of the Cervix)
12/2022
1Glioblastoma (Glioblastoma Multiforme)
10/2020
1Triple Negative Breast Neoplasms
03/2019
1Polyploidy
03/2019
1Liver Neoplasms (Liver Cancer)
12/2016
1Diabetic Nephropathies (Diabetic Nephropathy)
09/2011
1Type 2 Diabetes Mellitus (MODY)
06/2010
1Colonic Neoplasms (Colon Cancer)
06/2009
1Reperfusion Injury
08/2008
1Ischemia
08/2008
1Autoimmune Lymphoproliferative Syndrome
04/2008
1T-Cell Lymphoma (Lymphoma, T Cell)
04/2008

Drug/Important Bio-Agent (IBA)

16ascochlorinIBA
10/2020 - 04/2002
11Anti-Bacterial Agents (Antibiotics)IBA
10/2020 - 04/2002
10Proteins (Proteins, Gene)FDA Link
10/2020 - 04/2007
6ascofuranoneIBA
10/2020 - 06/2010
44-O-methylascochlorinIBA
10/2020 - 03/2011
4Transcription Factors (Transcription Factor)IBA
12/2019 - 03/2003
4Vinorelbine (Navelbine)FDA LinkGeneric
03/2019 - 04/2007
4Terpenes (Terpenoids)IBA
01/2018 - 12/2013
3DNA (Deoxyribonucleic Acid)IBA
04/2023 - 04/2005
370-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
12/2022 - 04/2012
3Epidermal Growth Factor (EGF)IBA
08/2020 - 04/2012
3Paclitaxel (Taxol)FDA LinkGeneric
03/2019 - 11/2007
3CaspasesIBA
12/2018 - 03/2003
3Estrogen ReceptorsIBA
11/2008 - 04/2005
2matrigelIBA
10/2020 - 04/2012
2Antineoplastic Agents (Antineoplastics)IBA
07/2019 - 03/2011
2AMP-Activated Protein KinasesIBA
03/2011 - 06/2010
2Peptides (Polypeptides)IBA
08/2010 - 04/2008
2Glucose (Dextrose)FDA LinkGeneric
06/2010 - 04/2007
2PPAR gammaIBA
07/2009 - 12/2006
2CytokinesIBA
05/2009 - 12/2006
2Fas Ligand Protein (Fas Ligand)IBA
08/2008 - 03/2008
2AlkaloidsIBA
04/2008 - 04/2007
2Transcription Factor AP-1 (Transcription Factor AP 1)IBA
11/2007 - 04/2005
2Matrix Metalloproteinase 9 (Gelatinase B)IBA
05/2007 - 07/2005
2Triglycerides (Triacylglycerol)IBA
10/2006 - 04/2002
2CholesterolIBA
10/2006 - 04/2002
2Phenol (Carbolic Acid)FDA Link
07/2005 - 04/2002
2prenylIBA
07/2005 - 04/2002
2OligodeoxyribonucleotidesIBA
06/2004 - 10/2003
2Proliferating Cell Nuclear Antigen (PCNA)IBA
10/2003 - 03/2003
1Ribosomal Protein S6 Kinases (S6 Kinase)IBA
12/2022
1TOR Serine-Threonine KinasesIBA
12/2022
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
12/2022
1Antiviral Agents (Antivirals)IBA
10/2020
1Mechanistic Target of Rapamycin Complex 1IBA
10/2020
1Actins (F Actin)IBA
10/2020
1Insulin-Like Growth Factor I (IGF-1)IBA
10/2020
1Mixed Function Oxygenases (Monooxygenases)IBA
12/2019
1IronIBA
12/2019
1NocodazoleIBA
03/2019
1ColchicineFDA LinkGeneric
03/2019
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2018
1tetrahydrofuranIBA
01/2017
1benzaldehydeIBA
01/2017
1Doxorubicin (Adriamycin)FDA LinkGeneric
12/2016
1Cadherins (E-Cadherin)IBA
12/2016
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
04/2015
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2012
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2012
1MetalsIBA
04/2012
1cobaltous chloride (cobalt(II)chloride)IBA
04/2012
1AntioxidantsIBA
09/2011
1Adenosine Triphosphate (ATP)IBA
03/2011
1Adenosine (Adenocard)FDA LinkGeneric
03/2011
1Deoxyribonucleases (DNase)FDA Link
01/2011
1Fluorouracil (Carac)FDA LinkGeneric
01/2011
1CladribineFDA LinkGeneric
01/2011
1Cisplatin (Platino)FDA LinkGeneric
01/2011
1pertuzumabIBA
08/2010
1CyclinsIBA
07/2010
1Transforming Growth Factor beta (TGF-beta)IBA
05/2009
1Transforming Growth Factors (Transforming Growth Factor)IBA
05/2009
1Plasminogen InactivatorsIBA
05/2009
1A-factor (Streptomyces)IBA
05/2009
1Phenobarbital (Luminal)FDA Link
11/2008
1Hormones (Hormone)IBA
11/2008
1Progesterone Receptors (Progesterone Receptor)IBA
11/2008
1LipopolysaccharidesIBA
03/2008
1Conditioned Culture MediaIBA
03/2008

Therapy/Procedure

7Therapeutics
01/2018 - 04/2005
2Segmental Mastectomy (Lumpectomy)
09/2010 - 07/2009
1Radiotherapy
12/2016
1Transplantation
08/2008